1204416-85-2
Chemical Structure
QAQ
- CAS No.: 1204416-85-2
- Formula:C28H44N6O22+
- Molecular Weight:496.69
IUPAC Name: (E)-2,2'-((diazene-1,2-diylbis(4,1-phenylene))bis(azanediyl))bis(N,N,N-triethyl-2-oxoethan-1-aminium)
InChIKey: PMJGZQTXCKBQOV-UHFFFAOYSA-P
SMILES: O=C(NC1=CC=C(/N=N/C2=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C2)C=C1)C[N+](CC)(CC)CC
Biological Activity: QAQ dichloride dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain[1][2].
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QAQ | QAQ dichloride dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain. | |||||||||||||||||||||
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References
- [1]. Timm Fehrentz, et al. Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers. Chembiochem. 2012 Aug 13;13(12):1746-9. [Content Brief]
- [2]. Alexandre Mourot, et al.Photochromic Potassium Channel Blockers: Design and Electrophysiological Characterization. Methods Mol Biol. 2013;995:89-105. [Content Brief]
