120447-62-3
120447-62-3
Chemical Structure
(±)-Vesamicol hydrochloride
Synonym(s): (±)-AH5183 hydrochloride
- CAS No.: 120447-62-3
- Formula:C17H26ClNO
- Molecular Weight:295.85
IUPAC Name: (1R,2R)-2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol hydrochloride
InChIKey: XJNUHVMJVWOYCW-GBNZRNLASA-N
SMILES: O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1.[H]Cl
Biological Activity: (±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(±)-Vesamicol hydrochloride | 99.79% | (±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively. | ||||||||||||||||||||
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References
- [1]. S M Efange, et al. N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J Med Chem. 1997 Nov 21;40(24):3905-14. [Content Brief]
- [2]. H Kobayashi, et al. Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res Bull. 1997;43(1):17-23. [Content Brief]
