1204918-73-9
1204918-73-9
Chemical Structure
(E/Z)-Zotiraciclib citrate
Synonym(s): (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate
- CAS No.: 1204918-73-9
- Formula:C29H32N4O8
- Molecular Weight:564.59
IUPAC Name: (E)-6-methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene 2-hydroxypropane-1,2,3-tricarboxylate
InChIKey: NWYDRHSNEATNRI-SQQVDAMQSA-N
SMILES: OC(C(O)=O)(CC(O)=O)CC(O)=O.CN1CC2=CC(NC3=NC(C4=CC(OCC/C=C/C1)=CC=C4)=CC=N3)=CC=C2
Biological Activity: (E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(E/Z)-Zotiraciclib citrate | 99.83% | (E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor. | ||||||||||||||||||||
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References
- [1]. William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012;55(1):169-196. [Content Brief]
