120512-32-5
120512-32-5
Chemical Structure
Anastrozole-d12
Synonym(s): ZD1033-d12
- CAS No.: 120512-32-5
- Formula:C17H7D12N5
- Molecular Weight:305.44
IUPAC Name: 2,2'-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene)bis(2-(methyl-d3)propanenitrile-3,3,3-d3)
InChIKey: YBBLVLTVTVSKRW-MGKWXGLJSA-N
SMILES: N#CC(C([2H])([2H])[2H])(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C#N)=CC(CN2C=NC=N2)=C1)C([2H])([2H])[2H]
Biological Activity: Anastrozole-d12 is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Anastrozole-d12 | 99.74% | Anastrozole-d12 is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM. | ||||||||||||||||||||
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Anastrozole (Standard) | 99.98% | Anastrozole (Standard) is the analytical standard of Anastrozole. This product is intended for research and analytical applications. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM. | ||||||||||||||||||||
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Anastrozole | 99.95% | Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Dukes M, et al. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45. [Content Brief]
