1206619-37-5
Chemical Structure
GSK2220691
- CAS No.: 1206619-37-5
- Formula:C32H33N5O3
- Molecular Weight:535.64
InChIKey: MSNUQZMCADJKQR-IBGGVINMSA-N
SMILES: O=C(N[C@@H](C(C)(C)C)C(N1[C@](C2)([H])CN(C(C3=CC=C(C4=CC=CC=C4)C=N3)=O)[C@]2([H])C1)=O)C5=CC6=C(N5)C=CC=C6
Biological Activity: GSK2220691 is a TRPV4 inhibitor. GSK2220691 inhibits agonist-induced calcium influx and downstream vascular leakage, and has anti-inflammatory effects, reducing neutrophil/macrophage infiltration, pro-inflammatory cytokines/chemokines, protein leakage, vascular injury markers, and blood oxygen desaturation, while protecting pulmonary and systemic vascular barrier function. GSK2220691 can be used in research on acute lung injury and phosgene-induced acute respiratory distress syndrome (ARDS)[1][2].
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GSK2220691 | 99.96% | GSK2220691 is a TRPV4 inhibitor. GSK2220691 inhibits agonist-induced calcium influx and downstream vascular leakage, and has anti-inflammatory effects, reducing neutrophil/macrophage infiltration, pro-inflammatory cytokines/chemokines, protein leakage, vascular injury markers, and blood oxygen desaturation, while protecting pulmonary and systemic vascular barrier function. GSK2220691 can be used in research on acute lung injury and phosgene-induced acute respiratory distress syndrome (ARDS). | ||||||||||||||||||||
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References
- [1]. Balakrishna S, et al. TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury. American journal of physiology. Lung cellular and molecular physiology. 2014 Jul 15;307(2):L158-72. [Content Brief]
- [2]. Long SM, et al. Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification. Toxicology and applied pharmacology. 2026 Oct;515:117985.
