1207258-55-6
1207258-55-6
Chemical Structure
NVS-CRF38
- CAS No.: 1207258-55-6
- Formula:C19H21N5O2
- Molecular Weight:351.40
IUPAC Name: 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole
InChIKey: MEICIUGVENCLKP-UHFFFAOYSA-N
SMILES: COC1=CC(C)=C(C2=C(C)OC3=C(N4N=C(C)N=C4C)C(C)=NN32)C=C1
Biological Activity:
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NVS-CRF38 | NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. | |||||||||||||||||||||
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References
- Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3. [Content Brief]
- Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42(7):1117-24. [Content Brief]
