120824-03-5
Chemical Structure
Withangulatin A
- CAS No.: 120824-03-5
- Formula:C30H38O8
- Molecular Weight:526.62
IUPAC Name: (4S,4aR,5aR,6aR,6bR,7S,9aR,11aS,11bR)-9-((S)-1-((R)-4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-4,6b-dihydroxy-9a,11b-dimethyl-1-oxo-1,4,5a,6,6a,6b,7,9a,10,11,11a,11b-dodecahydrocyclopenta[1,2]phenanthro[8a,9-b]oxiren-7-yl acetate
InChIKey: PLPXOWZTDPJPHC-ISIACCJKSA-N
SMILES: C[C@]12[C@@]3([C@H](C=CC2=O)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@]4([C@H](C=C5[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)C)C)OC(C)=O)O)C)([H])O3
Biological Activity: Withangulatin A is the inhibitor for COX-2. Withangulatin A inhibits MAPK, NF-κB, Akt/mTOR/p70S6K pathway, exhibits antitumor, anti-inflammatory and trypanocidal activities[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Withangulatin A | 99.76% | Withangulatin A is the inhibitor for COX-2. Withangulatin A inhibits MAPK, NF-κB, Akt/mTOR/p70S6K pathway, exhibits antitumor, anti-inflammatory and trypanocidal activities. | ||||||||||||||||||||
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References
- [1]. Lijuan Sun, et al. Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways. J Cell Biochem. 2010 Feb 15;109(3):532-41. [Content Brief]
- [2]. Liu Q, et al., Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways. Acta Pharmacol Sin. 2010 Aug;31(8):944-52. [Content Brief]
- [3]. Chen C, et al., Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biol. 2021 Oct;46:102130. [Content Brief]
