120925-60-2
120925-60-2
Chemical Structure
NA 0345
- CAS No.: 120925-60-2
- Formula:C27H24N4O3
- Molecular Weight:452.50
IUPAC Name: 7-hydroxy-8-methyl-7-((methylamino)methyl)-5,6,7,8,13,14-hexahydro-15H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-15-one
InChIKey: XRPFUJUZOIDJFP-DZXQMXLPSA-N
SMILES: O=C1NCC2=C(C3=C(N4[C@]5(C)OC6C[C@]5(CNC)O)C=CC=C3)C4=C7N6C8=CC=CC=C8C7=C21
Biological Activity: NA 0345 is a PKC inhibitor with IC50 values of 70 nM and 110 nM in the presence and absence of 12-O-tetradecanoyl-13-acetate, respectively. NA 0345 inhibits PKC and selectively suppresses the positive inotropic effect mediated by α1-adrenergic receptors[1].
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NA 0345 | NA 0345 is a PKC inhibitor with IC50 values of 70 nM and 110 nM in the presence and absence of 12-O-tetradecanoyl-13-acetate, respectively. NA 0345 inhibits PKC and selectively suppresses the positive inotropic effect mediated by α1-adrenergic receptors. | |||||||||||||||||||||
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