1213786-72-1
1213786-72-1
Chemical Structure
AN-3485 hydrochloride
- CAS No.: 1213786-72-1
- Formula:C14H14BCl2NO3
- Molecular Weight:325.98
IUPAC Name: 6-(4-(aminomethyl)-2-chlorophenoxy)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride
InChIKey: NKFCWFBFRRZSRG-UHFFFAOYSA-N
SMILES: OB1OCC2=CC=C(C=C12)OC3=CC=C(C=C3Cl)CN.[H]Cl
Biological Activity: AN-3485 hydrochloride is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 hydrochloride can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 hydrochloride also has certain anti-tumor activity[1][2].
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AN-3485 hydrochloride | AN-3485 hydrochloride is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 hydrochloride can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 hydrochloride also has certain anti-tumor activity. | |||||||||||||||||||||
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References
- [1]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. [Content Brief]
- [2]. Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25. [Content Brief]
