1214914-38-1
Chemical Structure
iso-WAY-260022
Synonym(s): iso-NRI-022
- CAS No.: 1214914-38-1
- Formula:C21H31F3N2O2
- Molecular Weight:400.48
SMILES: C[C@H](N[C@@H](C1)C)CN1C[C@@H](C2=CC(OC(F)(F)F)=CC=C2)C3(CCCCC3)O
Biological Activity: iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats[1].
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iso-WAY-260022 | iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats. | |||||||||||||||||||||
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