1215833-62-7
1215833-62-7
Chemical Structure
DMCM hydrochloride
- CAS No.: 1215833-62-7
- Formula:C17H19ClN2O4
- Molecular Weight:350.80
IUPAC Name: methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
InChIKey: FHCRBVQGMZUJKY-UHFFFAOYSA-N
SMILES: O=C(C1=C(CC)C2=C(C=N1)NC3=C2C=C(OC)C(OC)=C3)OC.[H]Cl
Biological Activity: DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DMCM hydrochloride | 99.11% | DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively. | ||||||||||||||||||||
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DMCM hydrochloride (Standard) | ≥98% | DMCM (hydrochloride) (Standard) is the analytical standard of DMCM (hydrochloride). This product is intended for research and analytical applications. DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 ?receptors, respectively. | ||||||||||||||||||||
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ZK 93426 hydrochloride | ZK 93426 (hydrochloride) is a benzodiazepine antagonist. ZK 93426 (hydrochloride) can be used for the research of neurological disease. |
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ZK-93426 | ZK-93426 is a benzodiazepine receptor antagonist. ZK-93426 does not alter the dogs' motility but induces generalized myoclonic jerks and tonic-clonic seizures. ZK-93426 can be used to study the mechanism of withdrawal reactions in the state of benzodiazepine dependence. | |||||||||||||||||||||
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ZK 95962 | ZK 95962 is an active compound. | |||||||||||||||||||||
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Quazodine | Quazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research. | |||||||||||||||||||||
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β-CCM | 98.95% | β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and proconvulsant effects. β-CCM enhances emotional reactivity and reduces vulnerability to interference in spatial working memory tasks. β-CCM can be used for research on anxiety-related disorders. | ||||||||||||||||||||
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Ethyl β-carboline-3-carboxylate | 99.75% | Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam. | ||||||||||||||||||||
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PDL1 degrader-3 | PDL1 degrader-3 (compound e24) is a DUBTAC-like PD-L1 degrader. PDL1 degrader-3 inhibits CSN5 enzymatic activity, increases PD-L1 ubiquitination, and induces PD-L1 degradation via the ubiquitin-proteasome pathway, reducing PD-L1 expression on tumor cell membranes. PDL1 degrader-3 blocks PD-1/PD-L1 interaction, activates the tumor immune microenvironment, enhances tumor-infiltrating T-cell immunity, and inhibits activation of immunosuppressive MDSCs and Tregs. PDL1 degrader-3 exerts antitumor effects in mouse tumor models. PDL1 degrader-3 can be used for the research of colorectal cancer, lung cancer. | |||||||||||||||||||||
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Glycozolidal | 99.92% | Glycozolidal (compound 12) is a carbazole alkaloid with antibacterial activity against P. gingivalis. Glycozolidal is cytotoxic against human gingival fibroblasts (HGFs) and monocytes (U937) in vitro with IC50 values of 120.86 µg/mL and 97.74 µg/mL, respectively. | ||||||||||||||||||||
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Clausine K | Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC50 = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC50 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods. | |||||||||||||||||||||
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4-Methoxy-β-carboline-1-carboxylic acid methylester | 4-Methoxy-β-carboline-1-carboxylic acid methylester is an alkaloid with the structure of canthin-6-one and β-carboline. | |||||||||||||||||||||
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