1217219-62-9
1217219-62-9
Chemical Structure
9-cis-Retinol acetate-d5
Synonym(s): 9-cis-Vitamin A acetate-d5;Zuretinol acetate-d5
- CAS No.: 1217219-62-9
- Formula:C22H27D5O2
- Molecular Weight:333.52
IUPAC Name: (2E,4E,6Z,8E)-9-(6,6-dimethyl-2-(methyl-d3)cyclohex-1-en-1-yl-3,3-d2)-3,7-dimethylnona-2,4,6,8-tetraen-1-yl acetate
InChIKey: QGNJRVVDBSJHIZ-DCNQKGDESA-N
SMILES: CC1(C(/C=C/C(C)=C\C=C\C(C)=C\COC(C)=O)=C(C([2H])(CC1)[2H])C([2H])([2H])[2H])C
Biological Activity: 9-cis-Retinol acetate-d5 is the deuterium labeled 9-cis-Retinol acetate. 9-cis-Retinol acetate is a retinal derivative[1][2].
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9-cis-Retinol acetate-d5 | 9-cis-Retinol acetate-d5 is the deuterium labeled 9-cis-Retinol acetate. 9-cis-Retinol acetate is a retinal derivative. | |||||||||||||||||||||
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Retinyl acetate (Standard) | 98.23% | Retinyl acetate (Standard) is the analytical standard of Retinyl acetate. This product is intended for research and analytical applications. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities. | ||||||||||||||||||||
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Retinyl acetate-d4 | 99.4% | Retinyl acetate-d4 is the deuterium labeled Retinyl acetate. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities. | ||||||||||||||||||||
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Retinyl acetate-d3 | Retinyl acetate-d3 (ALK-001) is a deuterated Vitamin A. Retinyl acetate-d3 can be used for research of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). | |||||||||||||||||||||
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Retinyl acetate | 99.30% | Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities. | ||||||||||||||||||||
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13-cis-Retinyl acetate | 13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A. | |||||||||||||||||||||
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Isotretinoin | 99.90% | Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity. | ||||||||||||||||||||
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9-cis-Retinol acetate | 9-cis-Retinol acetate is a retinal derivative. | |||||||||||||||||||||
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Vitamin A | 99.18% | Vitamin A (Vitamin A1) is an endogenous metabolite. | ||||||||||||||||||||
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13-cis-Vitamin A | 13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter. | |||||||||||||||||||||
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Vitamin A Propionate | 98.91% | Vitamin A Propionate is an ester compound of vitamin A. In nutritional studies of foals, different doses have different effects on growth, serum biochemistry and hematological indicators. Too high or too low doses will produce adverse effects and are related to the vitamin A concentration in plasma, liver and kidneys. | ||||||||||||||||||||
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9-cis Retinol | 97.0% | 9-cis Retinol is an upstream precursor of 9-cis-Retinal (HY-W009310) and 9-cis-Retinoic acid (HY-15128). 9-cis Retinol serves as a reaction substrate for cRDH, ARAT and LRAT, participates in cellular uptake and isomerization processes, and can be oxidized to form 9-cis-Retinal in the biosynthetic pathway. 9-cis Retinol inhibits the activity of 9-cis retinaldehyde dehydrogenase, thereby blocking the biosynthesis of 9-cis-Retinoic acid. 9-cis Retinol is applicable for metabolism-related research. | ||||||||||||||||||||
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11-cis-Retinol | 11-cis-Retinol, a form of retinol, can bind to RDH5. 11-cis-Retinol promote dark adaptation and recovery of photoresponsiveness of red cones but not of red rods. | |||||||||||||||||||||
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Methyl retinoate | 95.01% | Methyl retinoate (Vitamin A acid methyl ester) is a derivative of vitamin A. Methyl retinoate causes degenerative changes in the seminiferous tubules in Sprague Dawley rats. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Hussain RM, Gregori NZ, Ciulla TA, Lam BL. Pharmacotherapy of retinal disease with visual cycle modulators. Expert Opin Pharmacother. 2018;19(5):471-481. [Content Brief]
