1217503-60-0
Chemical Structure
GO-Y078
- CAS No.: 1217503-60-0
- Formula:C22H24O7
- Molecular Weight:400.43
IUPAC Name: (1E,4E)-1-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)penta-1,4-dien-3-one
InChIKey: SKZNJIJSGSQNJQ-CDJQDVQCSA-N
SMILES: O(C)C1=C(OC)C(OC)=CC(/C=C/C(/C=C/C2=CC(OC)=C(O)C(OC)=C2)=O)=C1
Biological Activity: GO-Y078 is a curcumin (HY-N0005) analog. GO-Y078 activates p38/JNK1/2. GO-Y078 activates the MAPK pathway, Caspase 3/8/9, PARP, AP-1, DR5, and TP53, while inhibiting cIAP-1, XIAP, and NF-κB. GO-Y078 induces sub-G1/G2/M phase arrest and Apoptosis. GO-Y078 impairs angiogenesis. GO-Y078 can be used in research related to osteosarcoma, cervical cancer, oral squamous cell carcinoma, and peritoneal metastasis of gastric cancer[1][2][3][4][5].
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GO-Y078 | GO-Y078 is a curcumin (HY-N0005) analog. GO-Y078 activates p38/JNK1/2. GO-Y078 activates the MAPK pathway, Caspase 3/8/9, PARP, AP-1, DR5, and TP53, while inhibiting cIAP-1, XIAP, and NF-κB. GO-Y078 induces sub-G1/G2/M phase arrest and Apoptosis. GO-Y078 impairs angiogenesis. GO-Y078 can be used in research related to osteosarcoma, cervical cancer, oral squamous cell carcinoma, and peritoneal metastasis of gastric cancer. | |||||||||||||||||||||
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References
- [1]. Lu PW, et al. GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling. Pharmaceuticals (Basel, Switzerland). 2021 May 24;14(6):497.
- [2]. Lee CY, et al. GO-Y078 Triggers Program Cell Death in Human Cervical Cancer Cells Via MAPK Activation-Dependent Apoptotic Caspases Signaling. Integrative cancer therapies. 2026;25:15347354251411859.
- [3]. Chien MH, et al. Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity. Expert opinion on therapeutic targets. 2022 Apr;26(4):375-388.
- [4]. Sugiyama S, et al. A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization. Anti-cancer agents in medicinal chemistry. 2016;16(5):633-47.
- [5]. Kudo C, et al. Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo. BMC pharmacology. 2011 May 28;11:4.
