1217674-10-6
1217674-10-6
Chemical Structure
SB 258719 hydrochloride
- CAS No.: 1217674-10-6
- Formula:C18H31ClN2O2S
- Molecular Weight:374.97
IUPAC Name: (R)-N,3-dimethyl-N-(4-(4-methylpiperidin-1-yl)butan-2-yl)benzenesulfonamide hydrochloride
InChIKey: UIZKHTBWJSUGOV-UNTBIKODSA-N
SMILES: O=S(C1=CC=CC(C)=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O.[H]Cl
Biological Activity: SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases[1][2].
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SB 258719 hydrochloride | SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases. | |||||||||||||||||||||
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References
- [1]. Thomas DR, et al. Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. Br J Pharmacol. 1998;124(6):1300-1306. [Content Brief]
- [2]. Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44(8):1031-1037. [Content Brief]
