1217744-87-0
Chemical Structure
(R)-(-)-Felodipine-d5
- CAS No.: 1217744-87-0
- Formula:C18H14D5Cl2NO4
- Molecular Weight:389.28
IUPAC Name: 3-(ethyl-d5) 5-methyl (R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: RZTAMFZIAATZDJ-PXPDZFMISA-N
SMILES: [2H]C([2H])([2H])C([2H])([2H])OC(C1=C(C)NC(C)=C(C(OC)=O)[C@@]1([H])C2=C(C(Cl)=CC=C2)Cl)=O
Biological Activity: (R)-(-)-Felodipine-d5 is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].
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(R)-(-)-Felodipine-d5 | (R)-(-)-Felodipine-d5 is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier. | |||||||||||||||||||||
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References
- [1]. Johnson JD, et al. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther. 1983;226(2):330-334.;Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to r [Content Brief]
- [2]. Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019 Apr 18;10(1):1817. [Content Brief]
- [3]. Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019 Apr 18;10(1):1817. [Content Brief]
