1217851-84-7
Chemical Structure
Voriconazole N-oxide-d3
Synonym(s): Voriconazole oxynitride-d3
- CAS No.: 1217851-84-7
- Formula:C16H11D3F3N5O2
- Molecular Weight:368.33
IUPAC Name: 4-((2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl-1,1,1-d3)-5-fluoropyrimidine 1-oxide
InChIKey: KPLFPLUCFPRUHU-QLWAGJNOSA-N
SMILES: O[C@@](CN1N=CN=C1)(C2=CC=C(F)C=C2F)[C@@H](C([2H])([2H])[2H])C3=C(F)C=[N+]([O-])C=N3
Biological Activity: Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB)[1][2].
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Voriconazole N-oxide-d3 | Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB). | |||||||||||||||||||||
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Voriconazole N-oxide | Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB). | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Ona K, et, al. Voriconazole N-oxide and its ultraviolet B photoproduct sensitize keratinocytes to ultraviolet A. Br J Dermatol. 2015 Sep;173(3):751-9. [Content Brief]
