1219795-16-0
1219795-16-0
Chemical Structure
Diphenhydramine-d5 hydrochloride
- CAS No.: 1219795-16-0
- Formula:C17H17D5ClNO
- Molecular Weight:296.85
IUPAC Name: N,N-dimethyl-2-(phenyl(phenyl-d5)methoxy)ethan-1-amine hydrochloride
InChIKey: PCHPORCSPXIHLZ-BSBWQDPUSA-N
SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H].Cl
Biological Activity: Diphenhydramine-d5 (hydrochloride) is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Diphenhydramine-d5 hydrochloride | 99.84% | Diphenhydramine-d5 (hydrochloride) is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB). | ||||||||||||||||||||
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Diphenhydramine hydrochloride (Standard) | 99.90% | Diphenhydramine (hydrochloride) (Standard) is the analytical standard of Diphenhydramine (hydrochloride). This product is intended for research and analytical applications. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB). | ||||||||||||||||||||
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Diphenhydramine-d6 hydrochloride | 99.30% | Diphenhydramine-d6 (hydrochloride) is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB). | ||||||||||||||||||||
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Diphenhydramine hydrochloride | 99.93% | Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB). | ||||||||||||||||||||
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Diphenhydramine N-oxide | Diphenhydramine N-oxide is a metabolite of Diphenhydramine (HY-B0303). Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine can across the ovine blood-brain barrier (BBB) . | |||||||||||||||||||||
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Diphenhydramine N-oxide-d6 | Diphenhydramine N-?Oxide-d6 is the deuterium labeled Diphenhydramine N-?Oxide. | |||||||||||||||||||||
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Toladryl | 97.23% | Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases. | ||||||||||||||||||||
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Toladryl (Standard) | ≥98% | Toladryl (Standard) is the analytical standard of Toladryl. This product is intended for research and analytical applications. Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases. | ||||||||||||||||||||
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4-Benzhydryloxy-piperidine-d5 | 4-(Diphenylmethoxy)piperidine-d5 is the deuterium labeled 4-(Diphenylmethoxy)piperidine. | |||||||||||||||||||||
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N-Desmethyl diphenhydramine-d3 (hydrochloride) | N-Desmethyl diphenhydramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl diphenhydramine hydrochloride. | |||||||||||||||||||||
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Orphenadrine-d3 | Orphenadrine-d3 is the deuterium labeled Orphenadrine. | |||||||||||||||||||||
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Orphenadrine | 99.71% | Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of [3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and CYP2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation. | ||||||||||||||||||||
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Doxylamine-d5 | 99.9% | Doxylamine-d5 is deuterium labeled Doxylamine (HY-A0069A). Doxylamine is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine is orally active, possessing analgesic and hypnotic activities. Doxylamine enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine can be used for the research of nausea, allergy, insomnia. | ||||||||||||||||||||
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Diphenhydramine | 99.85% | Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) . | ||||||||||||||||||||
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Diphenhydramine (Standard) | 98.69% | Diphenhydramine (Standard) is the analytical standard of Diphenhydramine. This product is intended for research and analytical applications. Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) . | ||||||||||||||||||||
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Diphenhydramine-d3 | Diphenhydramine-d3 is the deuterium labeled Diphenhydramine (HY-B0303). Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB). | |||||||||||||||||||||
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Benzyl benzoate-d5 | 99.81% | Benzyl benzoate-d5 is the deuterium labeled Benzyl benzoate. Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions. | ||||||||||||||||||||
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Orphenadrine hydrochloride | Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases. | |||||||||||||||||||||
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Orphenadrine hydrochloride (Standard) | ≥98% | Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases. | ||||||||||||||||||||
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Orphenadrine-d3 hydrochloride | Orphenadrine-d3 (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases. | |||||||||||||||||||||
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Bromodiphenhydramine | Bromodiphenhydramine (Ambodryl) is a potent antihistamine with antimicrobial property. Bromodiphenhydramine inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine can be used for cutaneous allergies research. | |||||||||||||||||||||
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Bromodiphenhydramine hydrochloride | 97.34% | Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research. | ||||||||||||||||||||
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2-(Benzhydryloxy)-N-methylethan-1-amine hydrochloride (Standard) | 99.83% | 2-(Benzhydryloxy)-N-methylethan-1-amine hydrochloride (Standard) is the analytical standard of 2-(Benzhydryloxy)-N-methylethan-1-amine hydrochloride. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Nordiphenhydramine-d3 | Nordiphenhydramine-d3 is the deuterium labeled Nordiphenhydramine. | |||||||||||||||||||||
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