1219803-65-2
1219803-65-2
Chemical Structure
3-Amino-2-methylpropanoic acid-d3
- CAS No.: 1219803-65-2
- Formula:C4H6D3NO2
- Molecular Weight:106.14
IUPAC Name: 3-amino-2-methylpropanoic-2,3,3-d3 acid
InChIKey: QCHPKSFMDHPSNR-UHVFUKFASA-N
SMILES: OC(C(C)([2H])C([2H])([2H])N)=O
Biological Activity: 3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-Amino-2-methylpropanoic acid-d3 | 3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. | |||||||||||||||||||||
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3-Aminoisobutyric acid (Standard) | 98.49% | 3-Aminoisobutyric acid (Standard) is the analytical standard of 3-Aminoisobutyric acid. This product is used for research and analytical applications. 3-Aminoisobutyric acid (β-Aminoisobutyric acid) exhibits anti-inflammatory and antioxidant effects. It increases the expression of brown fat cell-specific genes in white adipose tissue and enhances fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid alleviates insulin resistance and inflammation induced by palmitic acid or a high-fat diet in mice via the AMPK–PPARδ-dependent pathway. 3-Aminoisobutyric acid is a catabolite of thymine and valine in skeletal muscle. | ||||||||||||||||||||
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3-Aminoisobutyric acid | 98.0% | 3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle. | ||||||||||||||||||||
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3-Hydroxyisobutyric acid | 93.0% | 3-Hydroxyisobutyric acid is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis. | ||||||||||||||||||||
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L-2,3-Diaminopropionic acid | L-2,3-Diaminopropionic acid is the precursor of antibiotics and the siderophore staphyloferrin B. 2,3-Diaminopropionic acid is the inhibitor for polyphenoloxidase (PPO). | |||||||||||||||||||||
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(S)-β-Aminoisobutyric acid | 99.59% | (S)-β-Aminoisobutyric acid is an orally active S-isomer of β-Aminoisobutyric acid (HY-W012974). (S)-β-Aminoisobutyric acid can be produced through the catabolism of thymine and valine. (S)-β-Aminoisobutyric acid reduces apoptosis and increases the ratio of p-AMPK. (S)-β-Aminoisobutyric acid has cardioprotective effects. (S)-β-Aminoisobutyric acid is associated with acute aerobic exercise. | ||||||||||||||||||||
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Captopril EP Impurity C (Standard) | ≥98% | Captopril EP Impurity C (Standard) is the analytical standard of Captopril EP Impurity C. This product is intended for research and analytical applications. Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM). | ||||||||||||||||||||
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2-Methylbutanoic acid | 99.98% | 2-Methylbutanoic acid is a chemical intermediate for a variety of applications such as plasticizers, lubricants and pharmaceuticals. | ||||||||||||||||||||
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3-Amino-2-hydroxypropanoic acid | 98.0% | 3-Amino-2-hydroxypropanoic acid is a serine derivative. | ||||||||||||||||||||
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L-Isoserine | 98.0% | L-Isoserine is a serine derivative. | ||||||||||||||||||||
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Captopril EP Impurity D (Standard) | ≥98% | Captopril EP Impurity D (Standard) is the analytical standard of Captopril EP Impurity D (HY-W015332). This product is intended for research and analytical applications. Captopril EP Impurity D is an impurity of Captopril (HY-B0368). | ||||||||||||||||||||
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(S)-β-Aminoisobutyric acid hydrochloride | 99.90% | (S)-β-Aminoisobutyric acid hydrochloride is a cytoprotective agent, which is a non-proteinogenic amino acid enantiomer derived from valine metabolism in skeletal muscle mitochondria. The plasma level of (S)-β-Aminoisobutyric acid hydrochloride increases significantly after acute aerobic exercise (and is not affected by the AGXT2 rs37369 genotype), and it is secreted by mouse extensor digitorum longus and soleus muscles in ex vivo contraction assays. (S)-β-Aminoisobutyric acid hydrochloride specifically protects osteocytes from oxidative stress-induced cell death. | ||||||||||||||||||||
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(R)-b-Aminoisobutyric acid | 99.76% | (R)-β-Aminoisobutyric acid is a β-amino acid. (R)-β-Aminoisobutyric acid boosts myeloperoxidase microbicidal activity against susceptible microorganisms. (R)-β-Aminoisobutyric acid can be used for the research of bacterial infections. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Roberts LD, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 7;19(1):96-108. [Content Brief]
