1220699-39-7
1220699-39-7
Chemical Structure
PI3K/mTOR-IN-18
- CAS No.: 1220699-39-7
- Formula:C22H23N5O3
- Molecular Weight:405.45
SMILES: O=C1N([C@H]2CC[C@@H](CC2)O)C3=C(N1C)C=NC4=CC=C(C5=CN=C(OC)C=C5)N=C34
Biological Activity: PI3K/mTOR-IN-18 (Compound 12) is a highly selective dual PI3K/mTOR inhibitor. PI3K/mTOR-IN-18 shows antitumor effects via competitive binding to PI3Kα (Ki=0.130 nM) and mTOR (Ki=0.111 nM). PI3K/mTOR-IN-18 blocks the PI3K/AKT/mTOR pathway and inhibits tumor cell proliferation (IC50=144 nM). PI3K/mTOR-IN-18 is promising for research of solid tumors (e.g., breast, NSCLC)[1].
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PI3K/mTOR-IN-18 | PI3K/mTOR-IN-18 (Compound 12) is a highly selective dual PI3K/mTOR inhibitor. PI3K/mTOR-IN-18 shows antitumor effects via competitive binding to PI3Kα (Ki=0.130 nM) and mTOR (Ki=0.111 nM). PI3K/mTOR-IN-18 blocks the PI3K/AKT/mTOR pathway and inhibits tumor cell proliferation (IC50=144 nM). PI3K/mTOR-IN-18 is promising for research of solid tumors (e.g., breast, NSCLC). | |||||||||||||||||||||
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