1221186-53-3
1221186-53-3
Chemical Structure
TEPP-46
Synonym(s): ML-265
- CAS No.: 1221186-53-3
- Formula:C17H16N4O2S2
- Molecular Weight:372.46
IUPAC Name: 6-(3-aminobenzyl)-4-methyl-2-(methylsulfinyl)-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
InChIKey: ZWKJWVSEDISQIS-UHFFFAOYSA-N
SMILES: O=C1C(N(C)C2=C3SC(S(C)=O)=C2)=C3C=NN1CC4=CC=CC(N)=C4
Biological Activity: TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR[1][2][3].
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TEPP-46 | 99.77% | TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR. | ||||||||||||||||||||
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TEPP-46 (Standard) | ≥98% | TEPP-46 (Standard) is the analytical standard of TEPP-46 (HY-18657). This product is intended for research and analytical applications. TEPP-46 (ML-265) is a potent and selective pyruvate Kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR. | ||||||||||||||||||||
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References
- [1]. Anastasiou D, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct;8(10):839-847. [Content Brief]
- [2]. Palsson-McDermott EM, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21(1):65-80. [Content Brief]
- [3]. Goran Hamid Mohammad, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel). 2019 Sep 16;11(9):1372. [Content Brief]
