1221349-53-6
1221349-53-6
Chemical Structure
TC-I 2014
- CAS No.: 1221349-53-6
- Formula:C23H19F6N3O
- Molecular Weight:467.41
IUPAC Name: 3-(7-(trifluoromethyl)-5-(2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-yl)-1-oxa-2-azaspiro[4.5]dec-2-ene
InChIKey: VSMFCZZEKTVDHM-UHFFFAOYSA-N
SMILES: FC(C1=CC=CC=C1C2=CC(C(F)(F)F)=C3C(N=C(C4=NOC5(CCCCC5)C4)N3)=C2)(F)F
Biological Activity: TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
TC-I 2014 | 99.07% | TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
TC-I 2014 (Standard) | ≥98% | TC-I 2014 (Standard) is the analytical standard of TC-I 2014 (HY-110199). This product is intended for research and analytical applications. TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
