1222-05-5
1222-05-5
Chemical Structure
Galaxolide
- CAS No.: 1222-05-5
- Formula:C18H26O
- Molecular Weight:258.40
IUPAC Name: 4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene
InChIKey: ONKNPOPIGWHAQC-UHFFFAOYSA-N
SMILES: CC1COCC2=CC3=C(C=C12)C(C)(C)C(C)C3(C)C
Biological Activity: Galaxolide is a polycyclic musk synthetic fragrance. Galaxolide possesses endocrine-disrupting activity and can exert anti-androgenic/estrogenic effects. Galaxolide exhibits in vivo androgenic activity in immature rats. Galaxolide can be used in studies related to endocrine disruption[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Galaxolide | 76.44% | Galaxolide is a polycyclic musk synthetic fragrance. Galaxolide possesses endocrine-disrupting activity and can exert anti-androgenic/estrogenic effects. Galaxolide exhibits in vivo androgenic activity in immature rats. Galaxolide can be used in studies related to endocrine disruption. | ||||||||||||||||||||
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Galaxolide-d6 (mixture of diastereomers) (>80%) | Galaxolide-d6 (mixture of diastereomers) (>80%) is the deuterium labeled Galaxolide (HY-W100026). Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), trigger oxidative stress and genotoxicity, and induce EROD and GST (Glutathione S-transferase) enzyme activity. | |||||||||||||||||||||
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References
- [1]. Cavanagh JE, et al. Assessment of endocrine disruption and oxidative potential of bisphenol-A, triclosan, nonylphenol, diethylhexyl phthalate, galaxolide, and carbamazepine, common contaminants of municipal biosolids. Toxicol In Vitro. 2018 Apr;48:342-349. d [Content Brief]
- [2]. Li M, et al. Galaxolide and Irgacure 369 are novel environmental androgens. Chemosphere. 2023;324:138329. [Content Brief]
- [3]. Simmons DB, et al. Interaction of Galaxolide® with the human and trout estrogen receptor-α. Sci Total Environ. 2010;408(24):6158-6164. [Content Brief]
