1222173-37-6
1222173-37-6
Chemical Structure
BI-4394
Synonym(s): MMP13-IN-3
- CAS No.: 1222173-37-6
- Formula:C24H22N4O5
- Molecular Weight:446.46
IUPAC Name: 4-((5-(2-(ethoxycarbonyl)-1H-indol-5-yl)-1-methyl-1H-pyrazole-3-carboxamido)methyl)benzoic acid
InChIKey: MMJPVSDTLGFIQW-UHFFFAOYSA-N
SMILES: O=C(C(N1)=CC2=C1C=CC(C3=CC(C(NCC4=CC=C(C(O)=O)C=C4)=O)=NN3C)=C2)OCC
Biological Activity: BI-4394 (MMP13-IN-3), a chemical probe, is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM[1]) for the potential treatment of osteoarthritis[2]. BI-4394 is >1000 selective over other MMPs[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BI-4394 | 99.09% | BI-4394 (MMP13-IN-3), a chemical probe, is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis. BI-4394 is >1000 selective over other MMPs. | ||||||||||||||||||||
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References
- [1]. Taylor SJ, et al. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54(23):8174-87. [Content Brief]
- [2]. Ruminski PG, et al. Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59(1):313-27. [Content Brief]
