122252-09-9
122252-09-9
Chemical Structure
PNU-37883
- CAS No.: 122252-09-9
- Formula:C21H35N3O
- Molecular Weight:345.52
InChIKey: GKCGWXNLOYTUNC-UHFFFAOYSA-N
SMILES: C(/NC1CCCCC1)(N2CCOCC2)=N\C34CC5CC(C4)CC(C3)C5
Biological Activity: PNU-37883 is a selective vascular KATP channel blocker. PNU-37883 prevents K+ efflux/hyperpolarization, inhibits KATP-mediated vasodilation, and does not alter vascular tone when used alone. PNU-37883 can be used in research on hypertension and viral infections[1][2][3][4][5][6].
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PNU-37883 | PNU-37883 is a selective vascular KATP channel blocker. PNU-37883 prevents K+ efflux/hyperpolarization, inhibits KATP-mediated vasodilation, and does not alter vascular tone when used alone. PNU-37883 can be used in research on hypertension and viral infections. | |||||||||||||||||||||
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References
- [1]. Mar GY, et al. Changes of imidazoline receptors in spontaneously hypertensive rats. International journal of experimental pathology. 2013 Feb;94(1):17-24. [Content Brief]
- [2]. Carlton-Carew SRE, et al. Stimulation of the calcium-sensing receptor induces relaxations through CGRP and NK1 receptor-mediated pathways in male rat mesenteric arteries. Physiological reports. 2024 Jun;12(12):e16125.
- [3]. Sancho M, et al. Electro-Metabolic Sensing Through Capillary ATP-Sensitive K⁺ Channels and Adenosine to Control Cerebral Blood Flow. bioRxiv. 2021 Mar 13.
- [4]. Sancho M, et al. Adenosine signaling activates ATP-sensitive K channels in endothelial cells and pericytes in CNS capillaries. Science signaling. 2022 Mar 29;15(727):eabl5405.
- [5]. Kelly JA, et al. Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis. Antiviral research. 2025 Jun;238:106167.
- [6]. Ekman M, et al. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle. European journal of pharmacology. 2012 May 15;683(1-3):238-45.
