1223877-07-3
1223877-07-3
Chemical Structure
Z218484536
- CAS No.: 1223877-07-3
- Formula:C11H10FN5O
- Molecular Weight:247.23
InChIKey: GIZRLVBPWGRRNX-GIDUJCDVSA-N
SMILES: O=C(N/N=C/C1=CNN=C1C2=CC=C(F)C=C2)N
Biological Activity: Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a Kd value of approximately 0.23 μM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model[1].
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Z218484536 | 97.65% | Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a Kd value of approximately 0.23 μM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model. | ||||||||||||||||||||
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