1224195-72-5
1224195-72-5
Chemical Structure
Cu(II)-Elesclomol
- CAS No.: 1224195-72-5
- Formula:C19H18CuN4O2S2
- Molecular Weight:462.05
InChIKey: UUSCWIGUMPDFDE-UHFFFAOYSA-L
SMILES: CN1[N-](C(C2)=O)[Cu+2]([S]=C3C4=CC=CC=C4)([S]=C1C5=CC=CC=C5)[N-](C2=O)N3C
Biological Activity: Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cu(II)-Elesclomol | 99.88% | Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer. | ||||||||||||||||||||
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References
- [1]. Brian B Hasinoff, et al. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). hem Pharmacol. 2015 Feb 1;93(3):266-76. [Content Brief]
- [2]. Hasinoff BB, et al. The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II). J Inorg Biochem. 2014 Aug;137:22-30. [Content Brief]
