1224601-12-0
Chemical Structure
Lys(MMT)-PAB-oxydiacetamide-PEG8-N3
- CAS No.: 1224601-12-0
- Formula:C55H77N7O14
- Molecular Weight:1060.24
IUPAC Name: (S)-2-(32-azido-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontanamido)-N-(4-(hydroxymethyl)phenyl)-6-(((4-methoxyphenyl)diphenylmethyl)amino)hexanamide
InChIKey: PKUIBTBLKQVEJS-XHIZWQFQSA-N
SMILES: O=C(NC1=CC=C(CO)C=C1)[C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)CCCCNC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4
Biological Activity: Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 | 95.05% | Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs). Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
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Phe-Lys(Trt)-PAB | 96.24% | Phe-Lys(Trt)-PAB is a cathepsin B substrate, and a cleavable ADC linker. Phe-Lys(Trt)-PAB acts as a lysosomally cleavable substrate for cysteine protease cathepsin B, with cleavage enabling linked anticancer drug release via self-immolative spacer . Phe-Lys(Trt)-PAB can be used for synthesis of ADCs. | ||||||||||||||||||||
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Azido-PEG4-Ala-Ala-Asn(Trt)-PAB | Azido-PEG4-Ala-Ala-Asn(Trt)-PAB is a cleavable ADC linker. | |||||||||||||||||||||
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Methoxy-Tr-NH-PEG7 | Methoxy-Tr-NH-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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Mal-amide-PEG8-Val-Ala-PAB-PNP | 95.33% | Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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Mal-amide-PEG8-Val-Cit-PAB-OH | Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure. | |||||||||||||||||||||
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MC-Phe-Lys(MMT)-PABOH | MC-Phe-Lys(MMT)-PABOH is a linker. MC-Phe-Lys(MMT)-PABOH can be used to synthesize the immunoconjugate BR96-Phe-Lys-PABC-DOX. MC-Phe-Lys(MMT)-PABOH can be used in the research of colorectal cancer and ovarian cancer. | |||||||||||||||||||||
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N3-PEG8-Oxydiacetamide-Phe-Lys(MMT)-PAB-PNP | N3-PEG8-Oxydiacetamide-Phe-Lys(MMT)-PAB-PNP (compound 18) is a pharmaceutical synthesis intermediate for the SN-38 (HY-13704) derivative. | |||||||||||||||||||||
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Azide-PEG12-Val-Arg-PAB | Azide-PEG12-Val-Arg-PAB is an ADC Linker and can be used for synthesis of ADCs. | |||||||||||||||||||||
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Fmoc-PEG6-Val-Cit-PAB-OH | Fmoc-PEG6-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell. | |||||||||||||||||||||
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Azido-PEG8-Amido-Val-Cit-PAB | Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido will react with DBCO, BCN or other alkyne groups through click chemistry. PEG spacer increases aqueous solubility. Reagent grade, for research purpose. | |||||||||||||||||||||
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