122481-75-8
![[D-Arg1,D-Trp5,7,9,Leu11]-Substance P Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p11405.gif "[D-Arg1,D-Trp5,7,9,Leu11]-Substance P Chemical Structure")
Chemical Structure
[D-Arg1,D-Trp5,7,9,Leu11]-Substance P
- CAS No.: 122481-75-8
- Formula:C81H110N20O12
- Molecular Weight:1555.87
InChIKey: QDZOEBFLNHCSSF-PFFBOGFISA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCC(N)=O)C(N[C@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CC=CC=C7)C(N[C@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CCCNC(N)=N)N
Biological Activity: [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is a potent inhibitor of cell growth in small cell lung cancer (SCLC). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is also a neuropeptide antagonist, capable of blocking colony formation stimulated by various neuropeptides (including vasopressin and bradykinin). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the mobilization of Ca2+ and the activation of mitogen-activated protein kinases induced by vasopressin or bradykinin. [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the growth of H-69 xenograft tumors in nude mice[1].
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[D-Arg1,D-Trp5,7,9,Leu11]-Substance P | [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is a potent inhibitor of cell growth in small cell lung cancer (SCLC). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is also a neuropeptide antagonist, capable of blocking colony formation stimulated by various neuropeptides (including vasopressin and bradykinin). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the mobilization of Ca2+ and the activation of mitogen-activated protein kinases induced by vasopressin or bradykinin. [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the growth of H-69 xenograft tumors in nude mice. | |||||||||||||||||||||
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