122520-86-9
122520-86-9
Chemical Structure
Tyrphostin AG213
Synonym(s): AG213
- CAS No.: 122520-86-9
- Formula:C10H8N2O2S
- Molecular Weight:220.25
IUPAC Name: (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide
InChIKey: ZGHQGWOETPXKLY-XVNBXDOJSA-N
SMILES: S=C(/C(C#N)=C/C1=CC=C(C(O)=C1)O)N
Biological Activity: Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].
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Tyrphostin AG213 | Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells. | |||||||||||||||||||||
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