122536-20-3
122536-20-3
Chemical Structure
CI-990
Synonym(s): PD-131112
- CAS No.: 122536-20-3
- Formula:C19H22FN5O4
- Molecular Weight:403.41
IUPAC Name: 7-((S)-3-((S)-2-aminopropanamido)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
InChIKey: ZVZRDFTXNAZBOX-UWVGGRQHSA-N
SMILES: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@@H](NC([C@@H](N)C)=O)CC4)=N3)C1=O)O
Biological Activity: CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis)[1][2].
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CI-990 | CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis). | |||||||||||||||||||||
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References
- [1]. Cohen MA, et al. Bacterial eradication by clinafloxacin, CI-990, and ciprofloxacin employing MBC test, in-vitro time-kill and in-vivo time-kill studies. J Antimicrob Chemother. 1998 Jun;41(6):605-14. [Content Brief]
- [2]. Cohen MA, et al. In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci. Antimicrob Agents Chemother. 1995 Sep;39(9):2123-7. [Content Brief]
