1226917-67-4
1226917-67-4
Chemical Structure
SB-277011 dihydrochloride
Synonym(s): SB-277011A dihydrochloride
- CAS No.: 1226917-67-4
- Formula:C28H32Cl2N4O
- Molecular Weight:511.49
IUPAC Name: N-((1r,4r)-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide dihydrochloride
InChIKey: HEZIOTGUXSPDAK-ONAIBGCWSA-N
SMILES: O=C(C1=CC=NC2=CC=CC=C12)N[C@H]3CC[C@H](CCN4CC5=C(C=C(C#N)C=C5)CC4)CC3.[H]Cl.[H]Cl
Biological Activity: SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
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SB-277011 dihydrochloride | SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. | |||||||||||||||||||||
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