1227962-62-0
1227962-62-0
Chemical Structure
Maritoclax
Synonym(s): Marinopyrrole A
- CAS No.: 1227962-62-0
- Formula:C22H12Cl4N2O4
- Molecular Weight:510.15
IUPAC Name: (4,4',5,5'-tetrachloro-1'H-[1,3'-bipyrrole]-2,2'-diyl)bis((2-hydroxyphenyl)methanone)
InChIKey: QYPJBTMRYKRTFG-UHFFFAOYSA-N
SMILES: OC1=CC=CC=C1C(C2=C(N3C(C(C4=CC=CC=C4O)=O)=CC(Cl)=C3Cl)C(Cl)=C(Cl)N2)=O
Biological Activity: Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Maritoclax | 99.52% | Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM). | ||||||||||||||||||||
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Maritoclax (Standard) | ≥98% | Maritoclax (Standard) is the analytical standard of Maritoclax. This product is intended for research and analytical applications. Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM). | ||||||||||||||||||||
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Homocarbonyltopsentin | 99.82% | Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM. | ||||||||||||||||||||
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5-LOX-IN-6 | 5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research. | |||||||||||||||||||||
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Antitumor agent-72 | Antitumor agent-72 (compound 6w) is a potent anticancer agent. Antitumor agent-72 has anticancer activity and induces apoptosis through activation of caspase-3 and cleavage of PARP. Antitumor agent-72 can be used for cancer research. | |||||||||||||||||||||
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2,7-Dichlorodihydrofluorescein | 98.65% | 2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent reactive oxygen species (ROS) probe with an excitation wavelength of 485-500 nm and an emission wavelength of 515-530 nm. 2,7-Dichlorodihydrofluorescein is first hydrolyzed by intracellular esterases and then oxidized by ROS to generate non-biomembrane-permeable, highly fluorescent 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF is positively correlated with the ROS concentration. 2,7-Dichlorodihydrofluorescein can undergo oxidation reactions with a variety of ROS (such as ·OH, H2O2, ONOO-, etc.) and is used to quantitatively detect the level of oxidative stress inside and outside cells. It is suitable for oxidative stress analysis in in vitro cell models and in vivo targeted delivery (such as liver-targeted liposomes). | ||||||||||||||||||||
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Pyrrolomycin D | Pyrrolomycins D is a member of the pyrrolomycin group of antibiotic found in the Actinosporangium sp. | |||||||||||||||||||||
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Pamoic acid | 99.69% | Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties. | ||||||||||||||||||||
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Pamoic acid disodium | 99.86% | Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect. | ||||||||||||||||||||
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4,6-Dibenzoylresorcinol | 4,6-Dibenzoylresorcinol is a phenol. | |||||||||||||||||||||
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2,2'-(1,3,5,7-Tetraoxo-5,7-dihydropyrrolo[3,4-f]isoindole-2,6(1H,3H)-diyl)dibenzoic acid | 2,2'-(1,3,5,7-Tetraoxo-5,7-dihydropyrrolo[3,4-f]isoindole-2,6(1H,3H)-diyl)dibenzoic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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4-(9H-Carbazol-9-yl)pyridine-2,6-dicarboxylic acid | 4-(9H-Carbazol-9-yl)pyridine-2,6-dicarboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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