1228580-11-7
Chemical Structure
ASP1126
- CAS No.: 1228580-11-7
- Formula:C26H26ClF6NO5
- Molecular Weight:581.93
IUPAC Name: 1-((7-((4-(2,2,2-trifluoroethoxy)-3-(trifluoromethyl)benzyl)oxy)-2H-chromen-3-yl)methyl)piperidine-4-carboxylic acid hydrochloride
InChIKey: LLYLBEQEAUKJEK-UHFFFAOYSA-N
SMILES: O=C(C1CCN(CC2=CC3=CC=C(OCC4=CC=C(OCC(F)(F)F)C(C(F)(F)F)=C4)C=C3OC2)CC1)O.[H]Cl
Biological Activity: ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1].
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ASP1126 | ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile. | |||||||||||||||||||||
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