1228650-83-6
Chemical Structure
JNJ-41443532
Synonym(s): CCR2 antagonist 5
- CAS No.: 1228650-83-6
- Formula:C22H25F3N4O3S
- Molecular Weight:482.52
IUPAC Name: N-(2-((1-((1r,4r)-4-hydroxy-4-(thiazol-5-yl)cyclohexyl)azetidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
InChIKey: CFKBNYUHQSQBSX-CYWCHRQTSA-N
SMILES: O=C(CNC(C1=CC(C(F)(F)F)=CC=C1)=O)NC2CN(C2)[C@](CC3)([H])CC[C@@]3(C4=CN=CS4)O
Biological Activity: JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). JNJ-41443532 displays a Ki of 9.6 µM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JNJ-41443532 | 99.65% | JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). JNJ-41443532 displays a Ki of 9.6 µM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease. | ||||||||||||||||||||
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