1229603-37-5
1229603-37-5
Chemical Structure
AZD2423
- CAS No.: 1229603-37-5
- Formula:C20H29ClFN5O2
- Molecular Weight:425.93
IUPAC Name: (R)-4-(4-(tert-butyl)piperazine-2-carbonyl)-N-(4-chloro-3-fluorophenyl)piperazine-1-carboxamide
InChIKey: SRWQVWAIVQXPJY-QGZVFWFLSA-N
SMILES: O=C(N1CCN(C([C@@H]2NCCN(C(C)(C)C)C2)=O)CC1)NC3=CC=C(Cl)C(F)=C3
Biological Activity: AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZD2423 | 99.34% | AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux . | ||||||||||||||||||||
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References
- [1]. AZD2423.
- [2]. John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423.
- [3]. Kalliomäki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154(5):761-7. [Content Brief]
