1231899-06-1
Chemical Structure
Anhydroicaritin-3,7-di-O-glucuronide
- CAS No.: 1231899-06-1
- Formula:C33H36O18
- Molecular Weight:720.63
InChIKey: ZTARJZTZQZQVKU-LATIIKCTSA-N
SMILES: C/C(C)=C\CC1=C2C(C(C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)=C(C4=CC=C(C=C4)OC)O2)=O)=C(C=C1O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)O
Biological Activity: Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus *Epimedium* in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin[1][2].
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Anhydroicaritin-3,7-di-O-glucuronide | Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus *Epimedium* in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin. | |||||||||||||||||||||
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References
- [1]. Rong Y, et al. Application of ultra high-performance liquid chromatography tandem mass spectrometry to investigate the regioselective glucuronidation of icaritin in vitro[J]. Journal of Pharmaceutical and Biomedical Analysis, 2018, 154: 444-453.
- [2]. Zhao H, et al. Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(15-16):1113-1124. [Content Brief]
