123226-28-8
Chemical Structure
CAY10789
- CAS No.: 123226-28-8
- Formula:C17H15NO2
- Molecular Weight:265.31
IUPAC Name: (3-(quinolin-2-ylmethoxy)phenyl)methanol
InChIKey: FARMNDXIOAHJMF-UHFFFAOYSA-N
SMILES: OCC1=CC=CC(OCC2=NC3=CC=CC=C3C=C2)=C1
Biological Activity: CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].
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CAY10789 | 99.84% | CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases. | ||||||||||||||||||||
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