1232840-87-7
Chemical Structure
PBT434 free base
Synonym(s): ATH434 free base
- CAS No.: 1232840-87-7
- Formula:C12H13Cl2N3O2
- Molecular Weight:302.16
InChIKey: LQNHWKHRUWSYBK-UHFFFAOYSA-N
SMILES: O=C1N(C)C(CNCC)=NC2=C1C(Cl)=CC(Cl)=C2O
Biological Activity: PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 free base has the potential for the research of Parkinson’s disease (PD)[1][2].
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PBT434 free base | PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 free base has the potential for the research of Parkinson’s disease (PD). | |||||||||||||||||||||
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References
- [1]. Finkelstein DI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathol Commun. 2017 Jun 28;5(1):53. [Content Brief]
- [2]. Bailey DK, et al. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS One. 2021 Jul 26;16(7):e0254794. [Content Brief]
