1233114-22-1
Chemical Structure
AM-643
- CAS No.: 1233114-22-1
- Formula:C36H40N4O4S
- Molecular Weight:624.80
IUPAC Name: 3-(3-(tert-butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid
InChIKey: XIPYFDKZPWWWGS-UHFFFAOYSA-N
SMILES: O=C(O)C(C)(C)CC1=C(SC(C)(C)C)C=2C=C(OCC3=NC=C(C=C3)C)C=CC2N1CC=4C=CC(=CC4)C5=NC=C(OC)C=N5
Biological Activity: AM-643 is a FLAP inhibitor with human IC50 of 2 nM, oral activity, and dermal activity.AM-643 selectively inhibits FLAP, reduces leukotriene biosynthesis and reduces inflammatory ear swelling.AM-643 can be used for the research of skin disorders involving leukotriene production[1].
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AM-643 | AM-643 is a FLAP inhibitor with human IC50 of 2 nM, oral activity, and dermal activity.AM-643 selectively inhibits FLAP, reduces leukotriene biosynthesis and reduces inflammatory ear swelling.AM-643 can be used for the research of skin disorders involving leukotriene production. | |||||||||||||||||||||
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