1234563-15-5
1234563-15-5
Chemical Structure
Epetraborole (R-mandelate)
Synonym(s): GSK-2251052 (R-mandelate); AN 3365 (R-mandelate)
- CAS No.: 1234563-15-5
- Formula:C19H24BNO7
- Molecular Weight:389.21
InChIKey: GKQOYBLEEYTDIB-DEZAYANASA-N
SMILES: OC([C@@H](C1=CC=CC=C1)O)=O.OCCCOC2=C3C([C@H](OB3O)CN)=CC=C2
Biological Activity: Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection research[1][2][3].
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Epetraborole (R-mandelate) | Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection research. | |||||||||||||||||||||
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References
- [1]. Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4. [Content Brief]
- [2]. O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. [Content Brief]
- [3]. Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52. [Content Brief]
