1234694-20-2
1234694-20-2
Chemical Structure
(+)-trans-C75
Synonym(s): (+)-C75
- CAS No.: 1234694-20-2
- Formula:C14H22O4
- Molecular Weight:254.32
IUPAC Name: (2R,3S)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
InChIKey: VCWLZDVWHQVAJU-NEPJUHHUSA-N
SMILES: O=C([C@@H](C1=C)[C@@H](CCCCCCCC)OC1=O)O
Biological Activity: (+)-trans-C75 ((+)-C75) is an enantiomer of C75 (HY-12364) (a fatty acid synthase inhibitor). (+)-trans-C75 is less potent than the racemic mixture or the (-) enantiomer in enhancing the cancer-killing ability of ionizing radiation. (+)-trans-C75 inhibits CPT1 and is an anorectic agent[1][2].
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(+)-trans-C75 | (+)-trans-C75 ((+)-C75) is an enantiomer of C75 (HY-12364) (a fatty acid synthase inhibitor). (+)-trans-C75 is less potent than the racemic mixture or the (-) enantiomer in enhancing the cancer-killing ability of ionizing radiation. (+)-trans-C75 inhibits CPT1 and is an anorectic agent. | |||||||||||||||||||||
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References
- [1]. Rae C, et al. Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75. Chirality. 2017 Jan;29(1):10-13. [Content Brief]
- [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [Content Brief]
