1235406-00-4
Chemical Structure
PF-05150122
- CAS No.: 1235406-00-4
- Formula:C24H21ClN6O3S2
- Molecular Weight:541.04
IUPAC Name: 4-(4-chloro-2-(1-(1-ethylazetidin-3-yl)-1H-pyrazol-5-yl)phenoxy)-3-cyano-N-(thiazol-4-yl)benzenesulfonamide
InChIKey: OGBDDOBYHJYBFF-UHFFFAOYSA-N
SMILES: N#CC1=CC(S(=O)(NC2=CSC=N2)=O)=CC=C1OC3=C(C4=CC=NN4C5CN(C5)CC)C=C(Cl)C=C3
Biological Activity: PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain signaling. PF-05150122 exhibited favorable biopharmacokinetic parameters in microdose studies, providing a basis for exploring its application in acute or chronic pain inhibition. The pharmacokinetic model of PF-05150122 predicted that at the corresponding oral dose, it could effectively reduce the 50% inhibitory concentration (IC50) of Nav1.7, demonstrating its inhibitory potential[1].
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PF-05150122 | PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain signaling. PF-05150122 exhibited favorable biopharmacokinetic parameters in microdose studies, providing a basis for exploring its application in acute or chronic pain inhibition. The pharmacokinetic model of PF-05150122 predicted that at the corresponding oral dose, it could effectively reduce the 50% inhibitory concentration (IC50) of Nav1.7, demonstrating its inhibitory potential. | |||||||||||||||||||||
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