1235835-17-2
Chemical Structure
MOG 37-46
- CAS No.: 1235835-17-2
- Formula:C59H83N17O14
- Molecular Weight:1254.40
InChIKey: GVEFNOFMRZOXRO-MGZASHDBSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)NC([C@@H](NC(CNC([C@@H](N)C(C)C)=O)=O)CC4=CNC5=CC=CC=C45)=O
Biological Activity: MOG 37-46 is a dominant immunodominant CD8+ T cell epitope. As a truncated version of MOG35-55, MOG 37-46 is recognizable by MOG 35-55-specific T cells, and serves as an autoantibody target at the dimer interface of the extracellular domain of myelin oligodendrocyte glycoprotein (MOG). MOG 37-46 stimulates MOG-specific CD8+ T cell lines and proinflammatory CD8+ T cells migrating into the central nervous system (CNS) to produce IFN-γ. MOG 37-46 is applicable to research related to experimental autoimmune encephalomyelitis[1][2][3].
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MOG 37-46 | MOG 37-46 is a dominant immunodominant CD8+ T cell epitope. As a truncated version of MOG35-55, MOG 37-46 is recognizable by MOG 35-55-specific T cells, and serves as an autoantibody target at the dimer interface of the extracellular domain of myelin oligodendrocyte glycoprotein (MOG). MOG 37-46 stimulates MOG-specific CD8+ T cell lines and proinflammatory CD8+ T cells migrating into the central nervous system (CNS) to produce IFN-γ. MOG 37-46 is applicable to research related to experimental autoimmune encephalomyelitis. | |||||||||||||||||||||
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References
- [1]. Ford ML, et al. Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis. European journal of immunology. 2005 Jan;35(1):76-85.
- [2]. Bettini M, et al. Pathogenic MOG-reactive CD8+ T cells require MOG-reactive CD4+ T cells for sustained CNS inflammation during chronic EAE. Journal of neuroimmunology. 2009 Aug 18;213(1-2):60-8.
- [3]. Clements CS, et al. The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 2003 Sep 16;100(19):11059-64.
