1236188-38-7
Chemical Structure
BMS-520
- CAS No.: 1236188-38-7
- Formula:C23H17F3N4O4
- Molecular Weight:470.40
IUPAC Name: 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
InChIKey: RRPYZEWVBYBTJC-UHFFFAOYSA-N
SMILES: O=C(O)C1CN(C1)CC2=CC=C(C=C2)C3=NOC(C4=C(C(C5=CC=CC=C5)=NO4)C(F)(F)F)=N3
Biological Activity: BMS-520 is a potent, orally active and selective sphingosine-1-phosphate 1 (S1P1) agonist with an EC50 of 0.47nM. BMS-520 shows ~3400-fold selectivity over S1P3. BMS-520 demonstrates impressive efficacy in a rat model of arthritis and in a mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. BMS-520 can be used for arthritis and EAE research[1].
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BMS-520 | BMS-520 is a potent, orally active and selective sphingosine-1-phosphate 1 (S1P1) agonist with an EC50 of 0.47nM. BMS-520 shows ~3400-fold selectivity over S1P3. BMS-520 demonstrates impressive efficacy in a rat model of arthritis and in a mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. BMS-520 can be used for arthritis and EAE research. | |||||||||||||||||||||
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