1236361-78-6
1236361-78-6
Chemical Structure
Pimasertib hydrochloride
Synonym(s): AS703026 hydrochloride; MSC1936369B hydrochloride
- CAS No.: 1236361-78-6
- Formula:C15H16ClFIN3O3
- Molecular Weight:467.66
InChIKey: HIEXZUXKTABHCP-PPHPATTJSA-N
SMILES: OC[C@@H](O)CNC(C1=CC=NC=C1NC2=C(C=C(C=C2)I)F)=O.Cl
Biological Activity: Pimasertib hydrochloride is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor[1][2].
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Pimasertib hydrochloride | Pimasertib hydrochloride is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor. | |||||||||||||||||||||
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References
- [1]. Kim K, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol, 2010, 149(4), 537-549. [Content Brief]
- [2]. Park SJ, et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8. [Content Brief]
