123642-27-3
123642-27-3
Chemical Structure
MDL 73811
- CAS No.: 123642-27-3
- Formula:C15H23N7O3
- Molecular Weight:349.39
IUPAC Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((Z)-4-aminobut-2-en-1-yl)(methyl)amino)methyl)tetrahydrofuran-3,4-diol
InChIKey: YWJCZGDVJQLZET-GGHFOJMISA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](CN(C)C/C=C\CN)O[C@H]1N2C=NC3=C(N)N=CN=C32
Biological Activity: MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT[1][2].
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MDL 73811 | MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT. | |||||||||||||||||||||
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References
- [1]. Brockway AJ, et al. Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. Bioorg Med Chem. 2017 Oct 15;25(20):5433-5440. [Content Brief]
- [2]. Brockway AJ , et al. Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis (Stuttg). 2016 Jul;48(13):2065-2068. [Content Brief]
