123691-29-2
123691-29-2
Chemical Structure
CGP36216
- CAS No.: 123691-29-2
- Formula:C5H14NO2P
- Molecular Weight:151.14
IUPAC Name: (3-aminopropyl)(ethyl)phosphinic acid
InChIKey: RWCIPYZWXPUGRM-UHFFFAOYSA-N
SMILES: O=P(CC)(CCCN)O
Biological Activity: CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders[1][2].
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CGP36216 | CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders. | |||||||||||||||||||||
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References
- [1]. William Howson, et al. Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity. Bioorganic & Medicinal Chemistry Letters. Volume 3, Issue 4, April 1993, Pages 515-518.
- [2]. J Ong, et al. CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415(2-3):191-5. [Content Brief]
