123714-50-1
Chemical Structure
Acetyl-Calpastatin(184-210)(human)
- CAS No.: 123714-50-1
- Formula:C142H230N36O44S
- Molecular Weight:3177.63
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)[C@H]3N(CCC3)C([C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@H](CO)NC([C@H](CCSC)NC([C@H]4N(CCC4)C([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Acetyl-Calpastatin(184-210)(human) | 98.57% | Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively. | ||||||||||||||||||||
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References
- [1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3. [Content Brief]
- [2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355. [Content Brief]
