124001-41-8
124001-41-8
Chemical Structure
ICI 216140
- CAS No.: 124001-41-8
- Formula:C45H65N13O8
- Molecular Weight:916.08
InChIKey: GRDFIRBNYAQRAT-QHOQUQLNSA-N
SMILES: O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C)C(N[C@H](C(N[C@@H](CC(C)C)C(NC)=O)=O)CC1=CN=CN1)=O)=O)=O)[C@@H](NC([C@@H](NC(C(C)C)=O)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C34
Biological Activity: ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ICI 216140 | 99.78% | ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure. | ||||||||||||||||||||
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References
- [1]. Camble R, et al. N-isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antaconist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 1989;45(17):1521-1527. [Content Brief]
- [2]. Zogovic B, et al. Intrathecal bombesin is sympathoexcitatory and pressor in rat. Am J Physiol Regul Integr Comp Physiol. 2011;301(5):R1486-R1494. [Content Brief]
