1241725-90-5
1241725-90-5
Chemical Structure
(S)-BI 2536
- CAS No.: 1241725-90-5
- Formula:C28H39N7O3
- Molecular Weight:521.65
InChIKey: XQVVPGYIWAGRNI-QFIPXVFZSA-N
SMILES: CC[C@@H]1N(C2CCCC2)C3=NC(NC4=C(C=C(C=C4)C(NC5CCN(CC5)C)=O)OC)=NC=C3N(C1=O)C
Biological Activity: (S)-BI 2536 is the enantiomer of BI 2536 (HY-50698). (S)-BI 2536 acts as an inhibitor of the BRD4 bromodomain and PLK1 kinase, with a Ki value of 54 nM against BRD4 and a Ki value of 0.42 nM against PLK1 kinase. (S)-BI 2536 exhibits anticancer activity against acute myeloid leukemia. (S)-BI 2536 can be used for the research of acute myeloid leukemia[1].
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(S)-BI 2536 | (S)-BI 2536 is the enantiomer of BI 2536 (HY-50698). (S)-BI 2536 acts as an inhibitor of the BRD4 bromodomain and PLK1 kinase, with a Ki value of 54 nM against BRD4 and a Ki value of 0.42 nM against PLK1 kinase. (S)-BI 2536 exhibits anticancer activity against acute myeloid leukemia. (S)-BI 2536 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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